International Journal of Cardiology HomeMobileTwitter Facebook YouTube RSS Feeds Login Register Register as a GuestRegister and Claim Your SubscriptionSubscribeArticles & IssuesFor AuthorsJournal InfoSubscribeISACHDMore PeriodicalsSearch Terms Search within Search Advanced Search< Previous ArticleNext Article >October 1, 2015Volume 196, Pages 127–131Comparison of dabigatran versus warfarin in diabetic patients with atrial fibrillation: Results from the RE-LY trial☆Michela Brambatticorrespondenceemail, Harald Darius, Jonas Oldgren, Andreas Clemens, Herbert H. Noack, Martina Brueckmann, Salim Yusuf, Lars Wallentin, Michael D. Ezekowitz, Stuart J. Connolly, Jeff S. HealeyReceived: March 23, 2015; Received in revised form: May 25, 2015; Accepted: May 26, 2015; Published Online: May 28, 2015Article has an altmetric score of 1DOI: http://dx.doi.org/10.1016/j.ijcard.2015.05.141 | Share on mendeleyShare on facebookShare on twitterShare on emailMore Sharing ServicesshowArticle InfoPurchase access to this article (PDF Included) $31.50 USD (24 hour online access)Subscribe to this title AbstractFull TextReferencesAbstractObjectiveDiabetes mellitus (DM) is frequent among patients with atrial fibrillation (AF). The RE-LY trial permits evaluation of patient characteristics, outcomes and the effectiveness of dabigatran etexilate among diabetic individuals.MethodsPatient characteristics and outcomes were compared between diabetic and non-diabetic patients and the relative efficacy of each dose of dabigatran (150 mg bid and 110 mg bid) versus warfarin was evaluated.ResultsOf 18,113 patients in RE-LY, 4221 patients (23.3%) had DM. Patients with DM were younger (70.9 vs. 71.7 years), more likely to have hypertension (86.6% vs. 76.5%), coronary artery disease (37.4% vs. 24.9%) and peripheral vascular disease (5.6% vs. 3.2%); (all p < 0.01). Time in therapeutic range for warfarin-treated patients was 65% for diabetic versus 68% for non-diabetic patients (p < 0.001). Regardless of assigned treatment, stroke or systemic embolism was more common among patients with DM (1.9% per year vs. 1.3% per year, p < 0.001). DM was also associated with an increased risk of death (5.1% per year vs. 3.5% per year, p < 0.001) and major bleeding (4.2% per year vs. 3.0% per year, p < 0.001). The absolute reduction in stroke or systemic embolism with dabigatran compared to warfarin was greater among patients with DM than those without DM (dabigatran 110 mg: 0.59% per year vs. 0.05% per year; dabigatran 150 mg: 0.89% per year vs. 0.51% per year).ConclusionsCompared to non-DM patients, AF patients with DM derive a greater absolute risk reduction in embolic events when treated with dabigatran. ClinicalTrials.gov Identifier: NCT00262600.Keywords:Diabetes mellitus, Atrial fibrillation, Stroke, Dabigatran, Warfarin, Oral anticoagulationTo access this article, please choose from the options belowLog InEmail/Username: Password: Remember me Forgot password?RegisterCreate a new accountPurchase access to this article$31.50 USD | Online access for 24 hoursClaim AccessIf you are a current subscriber with Society Membership or an Account Number, claim your access now.Subscribe to this titlePurchase a subscription to gain access to this and all other articles in this journal.Institutional AccessVisit ScienceDirect to see if you have access via your institution.☆All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.© 2015 Published by Elsevier Inc.Access this article onScienceDirectArticle ToolsPDF (242 KB)Email ArticleAdd to My Reading ListExport CitationCreate Citation AlertCited by in Scopus (1)Request PermissionsOrder Reprints(100 minimum order)Related ArticlesDiabetes mellitus and atrial fibrillation: Pathophysiological mechanisms and potential upstream therapiesInternational Journal of Cardiology, Vol. 184Sitagliptin and cardiovascular outcomes in diabetic patients with chronic kidney disease after acute myocardial infarctionPublication stage: In Press Corrected ProofInternational Journal of CardiologyDiabetes mellitus and risk of sudden cardiac death: A systematic review and meta-analysisInternational Journal of Cardiology, Vol. 177, Issue 2Sitagliptin and cardiovascular outcomes in diabetic patients with chronic kidney disease and acute myocardial infarction: A nationwide cohort studyInternational Journal of Cardiology, Vol. 181Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca2+ release events in a rodent model of early stage diabetes: The arrhythmogenic substrateInternational Journal of Cardiology, Vol. 202View AllAdvertisment< Previous ArticleNext Article >October 1, 2015Volume 196, Pages 127–131Copyright © 2015 Elsevier Inc. 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