Results: Weight loss among participants while on the low-calorie diet significantly reduced MetSyn
prevalence (33.9% versus 15.9%; P < 0.001) and MetSyn score (1.48 versus 4.45; P < 0.001).
During weight maintenance, significant changes in MetSyn score were observed between the
groups, with the highest increase detected in the LP/HGI group (P ¼ 0.039, partial h2 ¼ 0.023).
Protein, GI, and their interaction did not have isolated effects on study outcomes.