DISCUSSION
This multicenter trial, which is the largest trial of
its kind to date comparing the lipid-modifying efficacy
of statins, showed the greater efficacy of rosuvastatin
in reducing LDL cholesterol, compared with atorvastatin,
simvastatin, and pravastatin across dose ranges.
The significantly greater LDL cholesterol reduction
achieved with rosuvastatin 10 to 80 mg, compared
with atorvastatin 10 to 80 mg, which was an average
difference of 8.2% across the dose-range slopes, exceeded
the predefined clinically meaningful difference