The Food and Agriculture Organization of the United Nations/World Health Organization (FAO/WHO) defined probiotics as living microorganisms, which, once administered in appropriate amounts, confer a health profit on the host. Stimulation or improvement of the defense system may be a mode of action by that probiotic exerts a helpful impact to the host [10]. Probiotics definition was initially commissioned to Lilly and Stilwell [11] who expressed probiotics as substances secreted by one organism that stimulate another organism. The nomenclature was then employed in 1971 by Sperti [12] who delineated tissue extracts that stimulate microbes’ growth. The word was later described by Parker [13] in 1974 that advanced the definition by adding the word organisms, thereby describing probiotics as “Organisms and substances that exert beneficial effects on the host by balancing its intestinal microbes.” The definition was re-improved by Fuller [14] in 1989 whose explanation was as “a live microbial feed supplement which beneficially affects the host animal by improving its intestinal balance.” The term, probiotic was also defined by Gismondo et al. [15] as “for life,” originating from the Greek words “pro” and “bios.” Recently, scientific data proved that the application of probiotic to the host get beyond its effects on the intestinal region to other desired effects [16]. Gram et al. [17] broadened the definition by removing the restriction to the improvement to the intestine: “a live microbial supplement which beneficially affects the host animal by improving its microbial balance.” Moreover, Salminen et al. [16] addressed probiotics as any live and dead microbes or their cellular fractions exerted beneficial effects on the host. Biswas et al. [18] recorded an in vitro modulation of immune response in the head kidney cells, organ responsible for immunity, of the Japanese puffer fish (Takifugu rubripes) after supplementation of heat-killed probiotics isolated from the Mongolian dairy product