Hydrogen peroxide (H2O2) is necessary for the metabolism of
proteins, carbohydrates, fats, vitamins and minerals [21]. What’s
more, H2O2 helps regulate blood sugar and the cellular energy production.
Oxidative damages in the body are caused by the cellular
H2O2 imbalance as it plays an important role in cell signaling and
communication. Hydrazine hydrate (N2H4) is a basic and strong
reducing agent and its salts are used in the pharmaceutical industry
as an intermediate to produce drugs with different therapeutic
effects including decarboxylase inhibitors, antihypertensives and
antibacterials [22]. However, N2H4 is toxic and thought to be possible
human carcinogen. Thus, a simple, fast and low cost way is
needed for the determination of H2O2 and N2H4. Electrochemical
detection techniques have a series of advantages, such as
rapid response, ease of use and low-cost small-sized commercial
detectors [23], which can satisfy the demands mentioned above.
PtNPs have been demonstrated to lower the H2O2 and N2H4 oxidation/
reduction overvoltage efficiently [24–26]. Thus, PtNPs are an
ideal sensor platform for the determination of H2O2 and N2H4.
The aim of the present work is: (1) to electrodeposite PtNPs
with a double-template system at CuNPs/nanoZnO modified GCE;
(2) investigate the sensing properties of the PtNPs/nanoZnO/GCE
towards H2O2 and N2H4. The coalition of chemical replacement
action and template sacrifice electrodeposition will open a new way
for the synthesis of novel nanomaterials with unique morphology
and properties.