Highlights
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A degradative step is required for plasma membrane H+-ATPase activation by glucose.
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Lpx1p degrades tubulin from the Tubulin-H+-ATPase complex.
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Tubulin-H+-ATPase complex dissociation by Lpx1p results in H+-ATPase activation.
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Tubulin degradation by Lpx1p is an early event in the H+-ATPase activation mechanism.
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Tubulin proteolysis by Lpx1p is an essential step to reach H+-ATPase fast activation.