PVP Met granulates had a higher content of bound water compared to the VA64 Met granulates. Therefore, the sticking tendency of PVP Met granulates may be due to the higher content of bound water.
It has been shown that moisture content has a significant impact on tablet properties [18]. The VA64 Met granulates’ bound water content of below 0.4% and moisture absorbency (3.0% at 90% RH, 11% at 95% RH) might have a positive impact on the tablet properties.