For the reasons indicated above, adenine was tested in a concentration range up to 30 mM. Fig. 2 shows that adenine has a rather weak inhibitory effect with an IC50 = 7.4 ± 1.6 mM.
The kobs of the reaction decreases from5 min−1 in the absence of adenine to 0.015 min−1 in its presence at a concentration of 30 mM. Adenine possesses two functional groups: imidazole and amino. The effects of a series ofmolecules carrying the imidazole and/or the amino are shown in