Itai-itai is a disease that results from long-term cadmium poisoning. The name comes from Japan, where large numbers of people in the 1950s developed the condition because of the widespread presence of cadmium in one province’s water; itai-itai means ouch-ouch in Japanese. Itai-itai disease, or ouch-ouch sickness, gets its name from the cries of pain sufferers emit. The condition is quite painful, affecting the bones, kidneys and liver where the cadmium is stored.