On the other hand, Ginkgo flavone glycosides are able to read-ily cross the BBB (the barrier that separates and protects brain tissue from toxins and other potentially harmful substances cir-culating in blood). GBE also showed a prominent capacity to affect signal transduction mediating the oxidative stress plus its impact on neurosensory system. In addition, other recent stud-ies have demonstrated that, GBE protects prostaglandins I2 from degradation, thus enhancing their smooth muscle relaxing effect,increasing in flow of blood. This effect can enhance wash of ROS from affected tissue compartments. It also can normalize cells metabolism altered in case of enhanced oxidative stress by increas-ing glucose utilization by affected cells (Kaschel, 2009).