The objective of this special research study is the safety evaluation of the natural gas pipes based on ALA-ASCE 2001 standard. The pipe diameters used in this analysis range from 8 to 20 in. and at the depth of 1.5 m. The evaluation was based on calculating the operating strain combined with the earthquake induced strain consist of the impact from permanent ground deformation, impact from buoyancy due to liquefaction, impact from normal fault crossing, impact from seismic wave propagation at different intensities. The safety evaluation that, the impact from longitudinal permanent ground deformation of strain is decreased when increasing the size of pipe, the impact from transverse permanent ground deformation and impact from buoyancy due to liquefaction of strain are increased when increasing the size of pipe, the impact from seismic wave propagation at different intensities of strain is increased by PGA and the strain of the pipe place in the soft soil is higher than stiff soil. In all above cases, the strain does not exceed the allowable standard, the impact from normal fault crossing of strain was calculated value exceeds the allowable standards, the pipes are not safe in this case. Therefore, the design of the natural gas pipes should consider impacts from seismic even though it is not currently required by the prevailing standards in Thailand. Events to increase safety and prevent any dangers from gas leakage or gas natural gas pipe explosion