The article examines organization development (OD) approaches that can be used by universities in addressing challenges with intrinsic change initiatives. Particular focus is given to the OD process which includes organizational learning and is built on strategic human resource (HR) principles. It also explores the role of employee assistance programs and employee relations practices. The need for OD practices to deal with the presence of deep cultural resistance to change is emphasized. A study of higher education institutions found that working within a culture can affect the change process.