The methods described by Sykes et al. (1992) and Vogelstein and Kinzler (1999) have been modified and made commercially available in different formats. For example, microfluidics can be used to partition one nucleic acid sample into hundreds or even thousands of individual chambers for subsequent PCR amplification on a microfluidic chip (Warren et al. 2006, Ottesen et al. 2006, Fan and Stephen 2007). Other systems involve separation onto microarrays (Morrison et al. 2006) or spinning microfluidic discs (Sundberg et al. 2010) and droplet techniques based on oil-water emulsions (Hindson et al., 2011). These systems vary in the volume and number of samples required and partitions generated. Therefore, the different methods offer different resolution, precision, and cost per sample.