A Cochrane review of 6 trials, including 915
children, reported that paracetamol and ibuprofen use in children who are led to a lower mean temperature at 1 and 4 hours
compared with use of a single antipyretic (mean difference at
1 hour: −0.27°C; 95% CI −0.4 and −0.08; mean difference at
4 hours: −0.70°C; 95% CI −1.05 and 0.35)