Cell culture-based vaccines have been developed in order to address concerns about the limitations of egg-grown influenza vaccines. It was recognized that in the event of a pandemic, the available egg-grown influenza vaccine would be insufficient to meet global demand and that
supplies of vaccine, traditionally grown in hens’ eggs would be threatened if birds were also vulnerable to infection from the pandemic virus strain (as is the case with H5N1 (avian flu)). Additionally, increasing demand for seasonal influenza vaccines have also increased the need to explore new methods of influenza vaccine production