Grain soaking treatment could reduce phytates improving mineral and protein bioavailability. To evaluate the effects of soaking process with lactic acid on phytates and nutrient content (Fe, Zn, and proteins) from whole rice grain, a surface response methodology with a 32 factorial experimental design was used. The independent variables were time (24, 36 and 48 h) and temperature (35°, 45° and 55 °C) of soaking.