The intensity used in this study during high-intensity IT was close to that associated with maximal oxygen consumption for healthy C57BL/6J mice (i.e., 25 m/min, (Schefer and Talan, 1996)). Lerman et al. found that maximal treadmill speed for C57BL/6J mice was only 22.2 m/min (Lerman, et al.,2002).