viewed as an unimportant
antiviral effector cells in vivo,
at least in the context of infection
with the JHM strain,
response to this epitope is apparently
sufficient to protect mice from MHV-A59 infection as it is the
only identified CD8 T-cell epitope in the MHV-A59 genome
(16). Approximately 12% of the CD8 cells in the CNS of
MHV-A59-infected animals are specific for this epitope (as
measured by an intracellular gamma interferon [IFN-] assay).