folding enhancer and aggregation suppressor. In principle, folding enhancer enhances protein-protein interaction,while aggregation suppressor reduces side chain interactions [4, 17]. The folding enhancers facilitate interaction between proteins and thus increase the stability of proteins whereas aggregation suppressor reduces side chain interaction of folding intermediates without interfering wither folding process[4].Common additives used in refolding of recombinant are shown in Table 1.
proteins