In most programs, the role of the e-learning designer or e-teacher is increasingly complex. Providing a balance between identifying clear central objectives and designing activities that are open enough to respond to autonomous learning needs is a tricky prospect. Yet, it appears to be the only choice if we are to embrace the remarkable potential of electronic access to unlimited data and expertise. One can recognize a trend toward a higher level of customized learning (personalization, individualization, contextualization, and adaptive learning). Student involvement is often required throughout to promote autonomy and transfer. Collaboration and communication are no longer centered on the teacher and e-learning design must acknowledge this. It is obvious that e-learners can now pursue their own paths with or without the instructor and the challenge is for the design to allow for a variety of learning paths for the benefit of individual learners.