but all were enrolled for at least 2 years and were included in the
final analysis, censored for duration of observation.
The geometric mean homocysteine concentration at baseline,
measured among 3306 participants, was 11.5 mol/L in both
groups (Table 1). In the active group, the mean concentration
was 2.1 mol/L lower in countries with folic acid food fortification
than in those without fortification; in the placebo group,
this difference at baseline was 2.3 mol/L. At the end of the
trial, the mean homocysteine concentration was 9.3 mol/L in
the vitamin therapy group and 12.3 mol/L in the placebo
group, indicating a decrease of 2.2 mol/L and an increase of
0.80 mol/L, respectively.