Cannabis has been used in medicine for thousands of years prior to achieving its current illicit substance status.
Cannabinoids, the active components of Cannabis sativa, mimic the effects of the endogenous cannabinoids
(endocannabinoids), activating specific cannabinoid receptors, particularly CB1 found predominantly in the central nervous
system and CB2 found predominantly in cells involved with immune function. Delta-9-tetrahydrocannabinol, the main bioactive
cannabinoid in the plant, has been available as a prescription medication approved for treatment of cancer
chemotherapy-induced nausea and vomiting and anorexia associated with the AIDS wasting syndrome. Cannabinoids may
be of benefit in the treatment of cancer-related pain, possibly synergistic with opioid analgesics. Cannabinoids have been
shown to be of benefit in the treatment of HIV-related peripheral neuropathy, suggesting that they may be worthy of study
in patients with other neuropathic symptoms. Cannabinoids have a favorable drug safety profile, but their medical use is
predominantly limited by their psychoactive effects and their limited bioavailability.
Cannabis has been used in medicine for thousands of years prior to achieving its current illicit substance status.Cannabinoids, the active components of Cannabis sativa, mimic the effects of the endogenous cannabinoids(endocannabinoids), activating specific cannabinoid receptors, particularly CB1 found predominantly in the central nervoussystem and CB2 found predominantly in cells involved with immune function. Delta-9-tetrahydrocannabinol, the main bioactivecannabinoid in the plant, has been available as a prescription medication approved for treatment of cancerchemotherapy-induced nausea and vomiting and anorexia associated with the AIDS wasting syndrome. Cannabinoids maybe of benefit in the treatment of cancer-related pain, possibly synergistic with opioid analgesics. Cannabinoids have beenshown to be of benefit in the treatment of HIV-related peripheral neuropathy, suggesting that they may be worthy of studyin patients with other neuropathic symptoms. Cannabinoids have a favorable drug safety profile, but their medical use ispredominantly limited by their psychoactive effects and their limited bioavailability.
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