Gestational age plays a role in determining surgical candidacy.
Traditionally, surgery is reserved for patients in the second trimester, given the higher risk in the first and third trimesters.
First-trimester surgery is avoided due to incomplete organogenesis, and third-trimester surgery has been discouraged because it is associated with a higher risk of preterm labor.
In addition, there is a reported 58% fetal mortality associated with third-trimester parathyroidectomy.
This mortality rate includes all postoperative complications for the infant, such as premature delivery, intrauterine growth retardation, infant hypocalcemia, neonatal death, and stillbirth.
It is impossible to differentiate surgical complications from complications of prolonged hypercalcemia related to the underlying disease process
Gestational age plays a role in determining surgical candidacy.Traditionally, surgery is reserved for patients in the second trimester, given the higher risk in the first and third trimesters. First-trimester surgery is avoided due to incomplete organogenesis, and third-trimester surgery has been discouraged because it is associated with a higher risk of preterm labor.In addition, there is a reported 58% fetal mortality associated with third-trimester parathyroidectomy. This mortality rate includes all postoperative complications for the infant, such as premature delivery, intrauterine growth retardation, infant hypocalcemia, neonatal death, and stillbirth. It is impossible to differentiate surgical complications from complications of prolonged hypercalcemia related to the underlying disease process
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