increases noradrenergic and serotonergic
neurotransmission via central α2 adrenoceptors. The
increased release of 5HT stimulates 5HT1 receptors, whilst
5HT2 and 5HT3 receptors are blocked. H1 receptors are
also blocked. This combination of actions appears to be
associated with antidepressant activity, anxiolytic and
sedative effects. Reported adverse effects include increased
appetite, weight gain, drowsiness, dry mouth and (rarely)
blood dyscrasias.