Items 51-55 It is not yet known whether clones will develop and age normally or whether subtle failures in genomic reprogramming or genetic imprinting might lead to various defects. Theoretically, tissues generated from cells cloned from a patient's own adult nucleus should not trigger an immune response, but it is possible that subtle differences caused by the foreign cytoplasm in the donor egg might cause a rejection response. Although scientists at Duke University suggested that human clones might not experience the problems encountered in cloned animals, the risk remains very high and quite unpredictable. Scientists generally agree that human reproductive cloning should not be permitted before the scientific and technical issues have been clarified. After a heated debate about human cloning in 2001. the us. House of Representatives voted 265-162 to institute a total federal ban on human cloning The bill included penalties of up to 10 years in prison and a $1 million fine. The House rejected competing measures that would have banned cloning for reproductive purposes while allowing non-reproductive or therapeutic cloning for scientific research. Non-reproductive cloning is legal in the United Kingdom. Since the early 1990s, British scientists have been allowed to create human embryos for research purposes and perform experiments in therapeutic cloning. The Human Fertilization and Embryology Act of 1990 established a system for regulating the creation and use of embryos.