More recently, 3 trials were done to evaluate glycoprotein IIb/IIIa antagonists as adjuncts to oral anti- platelet therapy in patients with primary PCI.54-56 The results bring into question whether glycoprotein IIb/IIIa antagonists provide additional benefit to STEMI patients who received dual antiplatelet therapy before catheterization. The ACC/AHA guidelines judge that routine use of glycoprotein IIb/IIIa antagonists for such patients cannot be recommended, although some patients (eg, those with a large thrombusburden or who received inadequate thienopyridine loading) may benefit. Clinical practices with these and other antithrombotic agents continue to evolve.