Mechanism of Action
Description: Amoxicillin inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to 1 or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesis resulting in bacterial lysis.
Pharmacokinetics:
Absorption: Rapidly and completely absorbed from the GI tract. Time to peak plasma concentration: 1-2 hr.
Distribution: Widely distributed into body tissues and fluids. Crosses the placenta and enters breast milk (small amounts). Plasma protein binding: Approx 20%.
Metabolism: Undergoes partial hepatic metabolism and converted to penicilloic acid.
Excretion: Via urine (60% as unchanged drug) and faeces. Plasma half-life: 1-1.5 hr.