3.2.1. Epidemiology
Before the 1990s MRSA was only known as a
healthcare-associated disease in hospitals. At that
time MRSA infection cases appeared in communities
without any records of hospitalization. CA-MRSA is
a moderately severe infection of the human skin and
soft tissues. At present, CA-MRSA has emerged in
most areas of the world. All of the Staphylococcus
aureus species have appeared in CA-MRSA strains
(71). The terrible spread of CA-MRSA is thought to be
associated with strengthened virulence and increased
transmissibility compared to former HA-MRSA. In the
last decade, much research was performed to illuminate
the molecular mechanism of virulence, but research on
transmissibility did not make much progress (