As the intensity of the HPP treatment increases,the rennet coagulation time of skim milk increases, similar to that forheat-treated milk, because more extensive whey protein denaturationcauses interaction between β-LG and κ-casein, which, in turn, resultsslows the release of the casein macropeptide (Lopez-Fandino et al.,1996; Naik et al., 2013; San Martín-Gonzalez ´ et al., 2006).