In another recent study [69], we evaluated the skin cancer chemopreventive
effects of resveratrol in a photocarcinogenesis model
of skin cancer. In this study, we employed a UVB initiation-promotion
protocol in which the control mice were subjected to chronic
UVB exposure (180 mJ/cm2
, twice weekly, for 28 weeks). The
experimental animals received either a pre-treatment (30 min before
each UVB) or post-treatment (5 min after UVB) of resveratrol
(25 or 50 lmol/0.2 ml acetone/mouse). The mice were followed
for skin tumorigenesis and were killed at 24 h after the last UVB
exposure, for further studies.