The RNA molecular is the basis of violence and pathogenesis of Dengue hemorrhagic fever (DHF) and Dengue Shock Syndrome (DSS) that must to know, to ensure that dengue vaccine development overcome of dengue virus evolution. The mechanisms of vaccine protection need to be clarified in future. The consensus immunogenic target of a neutralizing antibody response to all 4 serotypes of dengue virus in at least 80% of volunteers.