Therefore, we hypothesized that CFP
could also have endothelium dependent effects. Nitric oxide (NO)
was identified in 1987 as an important endothelial relaxing factor
[16], and the role of NO in arterial tone was clearly established
soon later [17]. This study actually demonstrates the involvement
of the endothelial relaxing factor NO in the blood pressure lowering effect and aorta relaxing effects of CFP in SHR.