The dissolution of chlorthalidone from the tablets is shown in Fig 1. In-vitro dissolution studies on the promising formulation CP1, PM1 is formulation containing physical mixture of superdisintegrants in 1:1 ratio, and CP0 control formulations were carried out in distilled water, and the various dissolution parameter values viz., percent drug dissolved in 4 min, 8 min, 12 min and 16 min (D4, D8 D12, and D16 ), t 50%, and t 90 % are shown in Table 4. This data reveals that among all the formulation CP1 shows nearly faster drug release. The formulations CP1 50 % of drug released in 4.25 min, and 90 % of drug released in 14 min, CP0 control formulations 50 % and 90 % of drug released were more than 20 min.