Based on this study, we speculate that low vitamin D levels may
lead to impaired wound healing in pediatric burn population,
adults with large burns, and patients with chronic non-healing
ulcers. There would appear to be an important balance between
vitamin D and TGFb1 levels, where high vitamin D levels in
concert with low TGFb1 levels improve wound healing, whereas
high vitamin D levels in concert with high TGFb1 levels reduce
fibrosis. This suggests that vitamin D modulates the wound
healing effects of TGFb1 differentially, depending on the TGFb1
concentration and underlying wound healing state, whether
this is impaired wound healing or fibrosis. Therefore, vitamin D
supplementation may be an effective therapy for improving
wound healing and also reducing fibrosis, a finding that is
certainly worthy of further investigation.