The purpose of this experiment is to test the inhibition effect of the cream on the S. epidermidis and antioxidant activity, which is extracted from Marigold. The method will follow the minimum standard from the Clinical and Laboratory Standards Institute in order to find the lowest viscosity of the minimum inhibitory concentration, MIC. The MIC value of the concentration found is under 1,024 µg/ml, which can be concluded that the Marigold extract has no inhibition effect on the bacteria as intended. Therefore we were unable to find the Minimum Bactericidal Concentration, MBC. We found the value of antioxidant of the Marigold by using the DPPH method or Radical Scavenging assay, by observing the ability of Ion attachment and the reduce ability. We discovered that from our experiment the viscosity of the antioxidant was 125, 250 and 500 µg/ml we found that per hundred the value of antioxidant is 22.35, 46.72 and 22.35 in order and has a IC50 value of 223.7 µg/ml and once we brought the extract of the Marigold to experiment with the cream base and tested with the antioxidant using the DPPH method, we discovered that the Marigold extract from the oxidant cream has no effect.