The molecular mechanism by which a cytoplasmic PLA2 may affect
membrane trafficking is unknown. PLA2 enzymes hydrolyze
phospholipids to generate a positive curve inducing lysophospholipid
and a free fatty acid. Localized accumulation of lysophospholipids
could affect membrane curvature and recruit effector
proteins that function in membrane bending and fission [21,22].
Moreover, our studies here are consistent with the growing realization
that a number of membrane trafficking events are facilitated
by the continual remodeling of the phospholipid:lysophospholipid
content [23,24].