Management of Gorham's disease is a challenge for clinicians. The medical treatment for Gorham's disease includes radiation therapy, antiosteoclastic medications (bisphosphonates),[21] and alpha-2b interferon.[22] Surgical options include resection of the lesion and reconstruction using bone grafts and/or prostheses. In most cases, bone grafts tend to undergo resorption and are not helpful. Unfortunately, no single treatment modality has proven effective in arresting the disease. In patients who receive high-dose radiation therapy, the potential for secondary malignancy and growth restriction exists and should be considered before embarking on this mode of treatment.[1]