Practitioners should evaluate each clinical situation balancing
the positive and negative aspects of each medication with gestationalage to determine which agent may be most suitable.
A meta-analysis concluded that hydralazine may have an increased incidence of maternal hypotension, headaches, and tachycardia.
Labetalol was found to have an increased risk of neonatal hypotension and may lead to increased incidence of intrauterine growth restriction.
Methyldopa has long been used to treat blood pressure conditions during pregnancy and is often considered to be the most commonly used antihypertensive agent during pregnancy.