The meta-regression analysis, which owing to the number of included randomised patients is considered ‘‘gold evidence’’,11 points towards recommending overweight patients with knee OA to reduce their body weight with at least 7.5%, obtained with an intensity being at least 0.6% per week would result in an at least moderate clinical effect. Finally, if we apply the general dietary (public health) approaches to reduce body weight64 to overweight patients with knee OA, using a rate of weight loss by 0.5 and 1.5 kg/week,61 the present meta-analysis shows that a 10% weight reduction will result in a moderate-to- large clinical effect according to self-reported disability (ES = 0.67), preferably reached within 12 weeks of treatment.