On the other hand, while we
can expect the unexpected, there are a fewclear directions for PEMT research
in the future. First, what needs to be explained is the mechanism(
s) by which large supplements of choline can override the
protection from obesity/insulin resistance observed in Pemt−/− mice
fed a high-fat diet. Second, it is possible that pharmaceutical inhibition
of PEMT might protect humans from atherosclerosis, obesity and type
2 diabetes.