The two oxygenated metabolites of arachidonic acid have potent and contrasting effects
on vascular tone and platelet function.
Inflammation has been implicated in pathogenesis of atherosclerosis and has been
shown to be associated with an increase in inflammatory biomarkers
such as an increase in the level of C-reactive protein
(CRP), vascular cell adhesion molecule (VCAM-1) and intercellular
adhesion molecule (ICAM-1).