HCdc14A overexpression increased cell survival compared with GFP transfection alone, but did not affect apoptosis significantly. (B, D) HCdc14A siRNA reduced cell survival and increased caspase-3 activity relative to control siRNA. n = 6; *p b 0.05 vs. control. # p b 0.05 GFP-hCdc14A vs. GFP or Si-hCdc14A vs. Si-con after combined stimulus. Si-con, control siRNA; Con, control.