Also we suggest the following methods to deliver and administrate of bacteria into human body with low immunogenicity:
Bioengineered bacterial outer membrane vesicles (OMVs) with low immunogenicity [32] that can produce biogas and also deliver biogas to the target. In regard to OMVs, the size of biogas producing bacteria should be smaller than OMVs. PEGylation: PEGylation defines the modification of a molecule by the linking of one or more polyethylene glycol (PEG) chains [33]. By PEGylation, we can delivered many biogas producing bacteria via IV route.