In order to further study the role of SVMPs in the pathophysiology induced by B. asper venom, and the potential role of MMP inhibitors in the treatment of snakebites, this study describes the ability of batimastat to inhibit the most relevant systemic effects induced by this
venom. Results evidence that SVMPs play a key role in the lethal, coagulant, defibrinogenating and hemorrhagic effects of B. asper venom, confirming the potential of metalloproteinase inhibitors in the therapy of snakebite envenomations.