Rick Riker (Drake Bell) is an unpopular, outcast student at Empire High School who lives with his Uncle Albert (Leslie Nielsen) and Aunt Lucille (Marion Ross) and has one friend and confidant, Trey (Kevin Hart). His crush is the breathtaking Jill Johnson (Sara Paxton), but she is dating bully Lance Landers (Ryan Hansen). One day, Rick and his class go on a school field trip at an animal research lab that is run by terminally ill businessman Lou Landers (Christopher McDonald), who is Lance's uncle. During the trip, Rick accidentally saturates himself in animal-attraction liquid, which causes a group of animals to hump him. This also leads a chemically enhanced radioactive dragonfly to fly onto Rick's neck and bite him.