Bio-based films derived from biopolymers can act as a barrier to gas and to other carriers such as antimicrobial, antioxidant, flavor and other food carrier substances. Nowadays, there has been interest in developing biopolymer films to replace synthetic materials such as plastics due to the biodegradable properties of biopolymer films. Several properly cross-linking aqueous solutions of cellulose ethers such as methylcellulose, hydroxypropyl methylcellulose and sodium carboxymethylcellulose are the most widely used cellulose derivatives. Hydroxypropyl methylcellulose (HPMC) is a hydrocolloid of a semi-synthetic polymer derived from cellulose that contains a basic repeating structure of anhydroglucose units and widely used in the food industry. HPMC provides higher degree of substitution of the cellulose derivatives than sodium