Most ingenane-type diterpenoids and 8-ene-7-one
triterpenoids (5–11) exhibited a relatively lower IC50 value; therefore, these compounds
had stronger cytotoxicity against human normal cell lines L-O2 and GES-1 with
dose-dependent relationships. These results will be significantly helpful to reveal the
mechanism of toxicity of kansui and to effectively guide safer clinical application of this herb.