Accordingly, we investigated the antimicrobial activities of WRPE ethanol fraction (WRPE-EtOH) and butanol fraction (WRPEBuOH) from R. hybrida against various microorganisms, including Gram-positive and -negative bacteria, as well as fungi. Notably, the Ministry of Food and Drug Safety (MFDS; www.mfds.go.kr) of the Republic of Korea approves 10 categories of Health Functional Foods, including “regulation of gastrointestinal physiology and function”, based on the “Guidelines for Health Functional Foods”.