The patient had severe septic shock with multiorgan failure, including diffuse intravascular coagulation and acute respiratory distress syndrome (ratio of PaO2 to fraction of inspired oxygen < 20 kPa). Massive fluid replacement (maximal cumulative fluid balance was 50 L positive) and high-dose vasopressor therapy were needed (for 8 days; norepinephrine maximum dose 2.7 μg/kg per minute and epinephrine maximum 0.08 μg/kg per minute). He was initially ventilated with high pressures (maximal positive end-expiratory pressure, 14 cm H2O) and high inspiratory oxygen, but he was not ventilated in prone position. After recovery from septic shock and extubation, he reported blindness in both eyes. His pupils were dilated and unresponsive to light. Ophthalmological evaluation revealed minimal peripapillary retinal hemorrhages without signs of papillary edema. Magnetic resonance imaging was performed but did not yield an explanation for his blindness. Visually evoked potentials were negative. The patient had bilateral ischemic optic neuropathy diagnosed.