Furthermore, the full-thickness skin wounds on Wistar rats demonstrated that, compared with gauze and the top side of the BC
film, the wound covered by the bottom side of the BC film showed faster recovery rate and less inflammatory response. The
results indicate that the platform based on the microfluidic chip provide a rapid, reliable, and repeatable method for wound
dressing screening. As an excellent biomaterial for wound healing, the BC film displays different properties on different sides,
which not only provides a method to optimize the biocompatibility of wound dressings but also paves a new way to building
heterogeneous BC-based biomaterials for complex tissue engineering.